Wednesday 8 August 2012

Benifits of Tramadol with Paracetamol


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Tramadol with Paracetamol has been shown to be particularly effective in treating human beings with nerve pain, which take care of not to respond to most "classic" opioids like morphine, hydrocodone or oxycodone. Tramadol is approximately as effective codeine in treating pain. Some find it to be highly effective and others find it to provide no noticeable analgesia. Many doctors believe that the analgesia Tramadol with Paracetamol produces is a result of synergism of the mu agonist action the inhibition of norepinephrine and serotonin reuptake, and the anti-inflammatory action.

Tramadol with Paracetamol has inhibitory actions on the 5-HT2C receptor. Antagonism of 5-HT2C could be partially responsible for tramadol's reducing effect on depressive and obsessive-compulsive symptoms in patients with pain and co-morbid neurological illnesses. 5-HT2C blockade may also account for its lowering of the seizure threshold, as 5-HT2C knockout mice display significantly increased vulnerability to epileptic seizures, sometimes resulting in spontaneous death. Tramadol's primary active metabolite, O-desmethyltramadol, is a considerably more potent ยต-opioid receptor agonist than tramadol itself, and is so much more so that Tramadol with Paracetamol can partially be thought of as a prod rug to O-desmethyltramadol. Similarly to tramadol, O-desmethyltramadol has also been shown to be a nor epinephrine reuptake inhibitor, 5-HT2C receptor antagonist, and M1 and M3 muscarinic acetylcholine receptor antagonist.


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