Tramadol with Paracetamol: Use of Tramadol with Paracetamol

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Tramadol is used similarly to codeine, to treat moderate to moderately severe pain. It has been suggested that tramadol could be effective for alleviating symptoms of depression, anxiety, and phobias because of its action on the noradrenergic and serotonergic systems, such as its "atypical" opioid activity. The warnings include more compelling language regarding the addictive potential of tramadol, the possibility of difficulty breathing while on the medication, a new list of more serious side effects, and a notice that tramadol is not to be used in place of opiate medications for addicts. Tramadol is also not to be used in efforts to wean addict patients from opiate drugs, nor to be used to manage long-term opiate addiction.

Paracetamol is a safe and effective analgesic that is used for relieving mild to moderate pain. Oral and rectal formulations of this drug are used as adjunct parts of balanced analgesic regimens peri operatively. Propacetamol is the water–soluble prod rug of paracetamol that can be used if increased efficacy or more rapid onset of action is desired. In the blood, this drug is easily broken to paracetamol and diethylglycin under the effect of plasma esterases. Each gram of Propacetamol is there for equal to 0.5 gram of paracetamol. Tramadol has been experimentally used in the form of an ingredient in multi-agent topical gels, creams, and solutions for nerve pain, rectal foam, concentrated retention enema, and a skin plaster quite similar to those used with lidocaine. Tramadol has a characteristic and unpleasant taste which is mildly bitter but much less so than morphine and codeine. Oral and sublingual drops and liquid preparations come with and without added flavoring. Its relative effectiveness via transmucosal routes is similar to that of codeine, and, like codeine, it is also metabolized in the liver to stronger metabolites.